Publications
As we advance our mission to develop breakthrough therapies that fundamentally change the way we treat, prevent, and control progressive and infectious respiratory diseases, we regularly share the progress of our research.
To learn more about our science and research findings, download the PDFs below:
Headache: The Journal of Head and Face Pain (2024) – PUR3100 - Safety, tolerability, and pharmacokinetics of a single orally inhaled dose of PUR3100, a dry powder formulation of dihydroergotamine versus intravenous dihydroergotamine: A Phase 1 randomized, double-blind study in healthy adults
A Phase 1 Study to Assess Safety, Tolerability, and Pharmacokinetics of PUR3100, a Novel Dry Powder Formulation of DHE for Oral Inhalation, in Healthy Adults
AAPS Journal (2023) – PUR1900 - Evaluation of the Potential for Drug-Drug Interactions with Inhaled Itraconazole Using Physiologically Based Pharmacokinetic Modelling, Based on Phase 1 Clinical Data
ACAAI – 2018 – A Phase 1/1B Study of an Inhaled Formulation of Itraconazole in Healthy Volunteers and Asthmatics
ERS – 2018 – PUR1800 (RV1162), A Novel Narrow Spectrum Kinase Inhibitor, but Not Fluticasone, Reduces TNFα-Induced Cytokine Release by Primary Bronchial Epithelial Cells from Healthy Volunteers and COPD Patients
ATS – 2018 – The Effect of RV1162 (PUR1800), A Novel Narrow Spectrum Kinase Inhibitor, on Viral Replication and Viral-Induced Inflammation in Primary Human Airway Cells
AAA8 – 2018 – Efficacy of PUR1900, An Inhaled Antifungal Therapy, in a Guinea Pig Model of Invasive Pulmonary Aspergillosis / PDF
NACFC – 2017 – Systemic and Pulmonary Exposure of PUR1900 Following Inhalation Dosing in Rats and Dogs Over 28 Days / PDF
RDD 2012 — Development of an iSPERSE™ Based Platform for the Delivery of Macromolecules via Dry Powder Formulations / PDF
RDD 2012 — Formulation Characterization of a Novel Levofloxacin Pulmonary Dry Powder Drug Delivery Technology / PDF
A Novel Inhaled Dry Powder Delivery Platform for the Delivery of Large Molecule Drugs to the Lung for Local and Systemic Treatments / PDF
RDD Europe 2011 - iSPERSE™: Formulation and In Vitro Characterization of a Novel Dry Powder Drug Delivery Technology / PDF
ATS 2011 — Efficacy of Fluticasone and Salmeterol in a Novel Inhaled Dry Powder Delivery Platform / PDF
ISAM 2011 Conference abstract — Deposition of Aerosolized Liquid Formulation in Ferrets by 3D CT / Spect Imaging / PDF
